The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

Nature. 1989 Jan 12;337(6203):138-43. doi: 10.1038/337138a0.


A gradient in concentration of the protein product of the bicoid gene is a determinant of the anterior-posterior axis of Drosophila embryos. By binding upstream of the segmentation gene hunchback the bicoid protein controls its transcription, thereby translating maternal pattern-generating information into differential activation of zygotic gene expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Drosophila / embryology
  • Drosophila / genetics*
  • Drosophila Proteins
  • Embryo, Nonmammalian / physiology
  • Genes
  • Genes, Regulator*
  • Homeodomain Proteins*
  • Insect Hormones / genetics*
  • Insect Hormones / physiology
  • Molecular Sequence Data
  • Restriction Mapping
  • Trans-Activators*
  • Transcription, Genetic*


  • Drosophila Proteins
  • Homeodomain Proteins
  • Insect Hormones
  • Trans-Activators
  • bcd protein, Drosophila