This descriptive study investigated the relationship between hope using the Herth Hope Scale and coping using the Jalowiec Coping Scale in 120 adult patients undergoing chemotherapy in hospital, outpatient, and home settings. Also analyzed were length of time since diagnosis, family and job responsibilities, and religious convictions in relation to the level of hope and coping. The study found a significant relationship (p less than 0.05) between level of hope and level of coping among subjects in all three settings. In addition, strength of religious convictions and performance of family role responsibilities were significantly related to the variables of hope and coping regardless of setting. Length of time since diagnosis and performance of job role responsibilities were not significantly related to either the levels of hope or coping.