Compassionate Use of Bacteriophage Therapy for Foot Ulcer Treatment as an Effective Step for Moving Toward Clinical Trials

Methods Mol Biol. 2018;1693:159-170. doi: 10.1007/978-1-4939-7395-8_14.

Abstract

We here present detailed descriptions of successful treatment of a series of diabetic toe ulcers using the Eliava BioPreparations' commercial preparation of the very well-studied anti-staphylococcal bacteriophage Sb-1. This chapter outlines what we feel is an appropriate mechanism to speed movement toward full-scale clinical trials with bacteriophage use to treat wound infections and to help address the crisis in antibiotic resistance.

Keywords: Amputation; Bacteriophage therapy; Debridement; Diabetic foot ulcers; Osteomyelitis.

MeSH terms

  • Bacterial Infections / complications*
  • Bacterial Infections / microbiology
  • Bacterial Physiological Phenomena
  • Bacteriophages*
  • Foot Ulcer / etiology
  • Foot Ulcer / therapy*
  • Humans
  • Phage Therapy*