Klebsiella Pneumoniaeoxa-48 in a Urology Patient: Case Report

Acta Clin Croat. 2017 Mar;56(1):166-171. doi: 10.20471/acc.2017.56.01.23.


We present an isolate of Klebsiella pneumoniae OXA-48 isolated in a 68-year-old man who underwent radical prostatectomy due to prostate cancer. The antibiotic susceptibility testing to a wide range of antibiotics was performed by disk diffusion method and determination of minimal inhibitory concentrations. The isolate was classified as multidrug-resistant. It showed intermediate susceptibility to imipenem and meropenem, resistance to ertapenem, and sensitivity only to colistin, amikacin, and trimethoprim-sulfamethoxazole. The isolate was positive for ESBLs, negative for AmpC. Polymerase chain reaction and sequencing revealed bla(OXA-48)', bla(CTX-M-15) and bla(SHV-11). The plasmid encoding OXA-48 ß-lactamase did not belong to any known PCR-based replicon typing. According to genotyping, the isolate belonged to ST37.

Keywords: Klebsiella pneumoniae – isolation and purification; Klebsiella infections; Prostatectomy – complications; Case reports.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Drug Resistance, Multiple, Bacterial / genetics
  • Genotype
  • Humans
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / genetics
  • Male
  • Microbial Sensitivity Tests
  • Polymerase Chain Reaction
  • Postoperative Complications / drug therapy
  • Postoperative Complications / microbiology*
  • Prostatectomy*
  • Prostatic Neoplasms / surgery*
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
  • Urinary Tract Infections / drug therapy
  • Urinary Tract Infections / microbiology*
  • beta-Lactamases / genetics


  • Anti-Bacterial Agents
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • beta-Lactamases
  • oxacillinase