The predictive value of microalbuminuria

Am J Kidney Dis. 1989 Jan;13(1):25-8. doi: 10.1016/s0272-6386(89)80110-6.


An elevated urinary albumin excretion (termed microalbuminuria) has been proposed as a predictor for later development of clinical diabetic nephropathy (hypertension, falling glomerular filtration rate [GFR], and urinary albumin excretion greater than 300 mg/24 h). However, review of the original reports on the predictability of microalbuminuria revealed a concomitant presence of elevated BP and a propensity to falling GFR. Thus, the predictability of microalbuminuria rests on the added evaluation of BP and GFR. Additional investigation is needed to address the possibility that microalbuminuria and either a rising BP or a falling GFR or both indicates established diabetic nephropathy rather than predicting its development.

MeSH terms

  • Albuminuria / complications
  • Albuminuria / urine*
  • Diabetic Nephropathies / physiopathology
  • Diabetic Nephropathies / urine*
  • Glomerular Filtration Rate
  • Humans
  • Hypertension / complications
  • Hypertension / diagnosis
  • Predictive Value of Tests