Mind Your Cs and Gs

Cell Host Microbe. 2017 Nov 8;22(5):575-576. doi: 10.1016/j.chom.2017.10.012.


How can an innate immune sensor shape viral evolution? In recent work, Takata et al. (2017) determined that the antiviral protein ZAP recognizes CG dinucleotide composition to differentiate self from non-self. This pressure may have driven CG dinucleotide suppression in HIV-1 and other RNA viruses to evade host antiviral defenses.

Publication types

  • Comment

MeSH terms

  • Antiviral Agents
  • HIV-1*
  • Humans
  • Immunity, Innate / immunology
  • RNA Viruses / genetics
  • Virus Replication / drug effects*


  • Antiviral Agents