Breaking the Barrier: Host Cell Invasion by Lujo Virus

Stefan Kunz; Juan Carlos de la Torre

doi:10.1016/j.chom.2017.10.014

Breaking the Barrier: Host Cell Invasion by Lujo Virus

Cell Host Microbe. 2017 Nov 8;22(5):583-585. doi: 10.1016/j.chom.2017.10.014.

Authors

Stefan Kunz¹, Juan Carlos de la Torre²

Affiliations

¹ Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland.
² Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. Electronic address: juanct@scripps.edu.

PMID: 29120740
DOI: 10.1016/j.chom.2017.10.014

Abstract

Lujo virus (LUJV) is an arenavirus that emerged in 2008 associated with a cluster of human cases of severe hemorrhagic fever. In this issue of Cell Host & Microbe, Raaben et al. (2017) identify neuropilin (NRP)-2 as cell surface receptor and the tetraspannin protein CD63 as intracellular entry factor for LUJV.

Publication types

Comment

MeSH terms

Arenavirus
Hemorrhagic Fevers, Viral / virology*
Humans
Lujo virus*
Receptors, Cell Surface

Substances

Receptors, Cell Surface