Optical Coherence Tomography Findings in Endogenous Fungal Chorioretinitis, Retinitis, and Endophthalmitis

Ophthalmic Surg Lasers Imaging Retina. 2017 Nov 1;48(11):894-901. doi: 10.3928/23258160-20171030-04.


Background and objective: To describe spectral-domain optical coherence tomography (SD-OCT) findings in eyes with endogenous fungal chorioretinitis and endophthalmitis.

Patients and methods: Retrospective, observational case series of subjects at Wills Eye Hospital and William Beaumont Hospital were identified by screening OCT billing data and cross-referencing with patient charts. Clinical and imaging data were collected for each patient and reviewed.

Results: Twelve eyes of seven consecutive patients were identified, demonstrating two patterns of posterior ocular involvement: chorioretinal infiltration and superficial retinal/retinal vascular infiltration without choroidal involvement. Six of 12 eyes had follow-up imaging performed after antifungal treatment, which demonstrated decreased size of choroidal and/or retinal infiltrates.

Conclusions: All patients with follow-up imaging had anatomic improvement by OCT of the lesions with treatment. In the future, OCT imaging may provide a method to assess therapeutic response and prognosis for visual recovery in patients with endogenous fungal ocular disease. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:894-901.].

Publication types

  • Multicenter Study
  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Antifungal Agents / therapeutic use
  • Candida albicans / isolation & purification
  • Candidiasis / diagnosis*
  • Candidiasis / drug therapy
  • Candidiasis / microbiology
  • Chorioretinitis / diagnosis*
  • Chorioretinitis / drug therapy
  • Chorioretinitis / microbiology
  • Endophthalmitis / diagnosis*
  • Endophthalmitis / drug therapy
  • Endophthalmitis / microbiology
  • Eye Infections, Fungal / diagnosis*
  • Eye Infections, Fungal / drug therapy
  • Eye Infections, Fungal / microbiology
  • Female
  • Fluorescein Angiography
  • Fungemia / diagnosis
  • Humans
  • Male
  • Middle Aged
  • Retinitis / diagnosis*
  • Retinitis / drug therapy
  • Retinitis / microbiology
  • Retrospective Studies
  • Tomography, Optical Coherence*
  • Visual Acuity / physiology


  • Antifungal Agents