Medication Management of Patients Undergoing Transcatheter Aortic Valve Replacement

Pharmacotherapy. 2018 Jan;38(1):122-138. doi: 10.1002/phar.2056. Epub 2017 Dec 25.


Aortic stenosis (AS) is the most common form of valvular heart disease. A detailed diagnostic workup is necessary to promptly stage and classify disease severity to determine optimal management. Medical therapy and valvuloplasty are options that fail to delay or reverse disease progression. Surgical aortic valve replacement (SAVR) is curative but has significant limitations for some patient populations. A newer option, transcatheter aortic valve replacement (TAVR), has become more widely available to patients with intermediate- or high-operative risk. Periprocedural medication management is imperative for successful valve implantation and to minimize adverse events. Stroke remains one of the most common complications of TAVR and is associated with increased mortality. Thus, intra- and postprocedural antithrombotic therapy is required, although the regimen that best minimizes thromboembolic events and bleeding complications has yet to be defined. Patients undergoing TAVR with comorbid conditions requiring oral anticoagulation or individuals who develop subvalvular thromboses pose unique challenges. Antiplatelet and anticoagulant therapy should be carefully balanced. This article summarizes key literature supporting the pharmacologic management of patients receiving TAVR.

Keywords: CoreValve; PARTNER; SAPIEN; anticoagulation; aortic stenosis; dual-antiplatelet therapy; transcatheter aortic valve implant; transcatheter aortic valve replacement.

Publication types

  • Review

MeSH terms

  • Anticoagulants / administration & dosage
  • Aortic Valve Stenosis / diagnosis
  • Aortic Valve Stenosis / pathology
  • Aortic Valve Stenosis / surgery*
  • Hemorrhage / prevention & control
  • Humans
  • Platelet Aggregation Inhibitors / administration & dosage
  • Risk Factors
  • Severity of Illness Index
  • Stroke / etiology
  • Stroke / mortality
  • Stroke / prevention & control*
  • Thromboembolism / etiology
  • Thromboembolism / prevention & control
  • Transcatheter Aortic Valve Replacement / adverse effects
  • Transcatheter Aortic Valve Replacement / methods*


  • Anticoagulants
  • Platelet Aggregation Inhibitors