[Cannabis and crossed allergy with food]

Rev Pneumol Clin. 2017 Dec;73(6):290-293. doi: 10.1016/j.pneumo.2017.09.003. Epub 2017 Nov 6.
[Article in French]


Cannabis use has increased over the last decade. At the same time, we see cannabis allergies appearing, ranging from simple rhinoconjunctivitis to anaphylactic-type reactions, some of which are severe since fatal cases have been described, but we also see allergic-induced food allergies cross-linked in the family of lipid transfer proteins (LTP). Indeed, cannabis contains an LTP called Can s 3. The LT are very widespread in the vegetable kingdom and are present in many vegetables and fruits. LTPs have a similar chemical structure and therefore cross-allergy is common. Thus, by becoming aware of the LTP of cannabis, it is possible to become allergic by a mechanism of cross-allergy to the other LTPs present in fruits and vegetables. This syndrome is referred to as cannabis-fruit-vegetable syndrome.

Keywords: Allergie; Allergie alimentaire; Allergy; Cannabis; Food allergy; LTP.

Publication types

  • Review

MeSH terms

  • Allergens / immunology
  • Cannabis / immunology*
  • Carrier Proteins / immunology
  • Cross Reactions / immunology
  • Food Hypersensitivity / immunology*
  • Humans


  • Allergens
  • Carrier Proteins
  • lipid transfer protein