Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration

Neurosci Bull. 2018 Apr;34(2):270-282. doi: 10.1007/s12264-017-0188-0. Epub 2017 Nov 10.


In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.

Keywords: Neurodegeneration; Neuroinflammation; Parkinson’s disease; REAC TO-RGN-N treatment.

MeSH terms

  • Animals
  • Corpus Striatum / pathology*
  • Electric Stimulation / methods*
  • Inflammation / pathology
  • Male
  • Mice
  • Nerve Degeneration / pathology
  • Nerve Regeneration / physiology
  • Parkinsonian Disorders / pathology*