Psycho-Neuro-Endocrine-Immunology: A Psychobiological Concept

Adv Exp Med Biol. 2017;996:123-134. doi: 10.1007/978-3-319-56017-5_11.


Psycho-Neuro-Endocrine-Immunology (P.N.E.I.) is a scientific field of study that investigates the link between bidirectional communications among the nervous system, the endocrine system, and the immune system and the correlations of this cross-talk with physical health. The P.N.E.I. innovative medical approach represents a paradigm shift from a strictly biomedical view of health and disease taken as hermetically sealed compartments to a more interdisciplinary one. The key element of P.N.E.I. approach is represented by the concept of bidirectional cross-talk between the psychoneuroendocrine and immune systems. The Low Dose Medicine is one of the most promising approaches able to allow the researchers to design innovative therapeutic strategies for the treatment of skin diseases based on the rebalance of the immune response.

Keywords: Homeostatic equilibrium; Low dose medicine; Psycho-Neuro-Endocrine- Immunology; Psychodermatology.

Publication types

  • Review

MeSH terms

  • Animals
  • Central Nervous System / immunology
  • Central Nervous System / metabolism
  • Central Nervous System / physiopathology*
  • Endocrine System / immunology
  • Endocrine System / metabolism
  • Endocrine System / physiopathology*
  • Holistic Health
  • Homeostasis
  • Humans
  • Immune System / immunology
  • Immune System / metabolism
  • Immune System / physiopathology*
  • Neuroimmunomodulation
  • Neurosecretory Systems / immunology
  • Neurosecretory Systems / metabolism
  • Neurosecretory Systems / physiopathology
  • Signal Transduction
  • Skin Diseases / immunology
  • Skin Diseases / physiopathology*
  • Skin Diseases / psychology*
  • Skin Diseases / therapy