Psychotic symptoms and the longitudinal course of senile dementia of the Alzheimer type

Biol Psychiatry. 1989 Jan;25(1):39-48. doi: 10.1016/0006-3223(89)90145-5.


Delusions, misidentifications and hallucinations occur frequently throughout the course of senile dementia of the Alzheimer type (SDAT). Rates of psychosis among subjects with moderate to severe SDAT range from 42% to 84% in our study group; at least half of persons with SDAT with no prior psychiatric history will display psychosis at some point during the course of dementia. Furthermore, psychotic symptoms are associated with accelerated cognitive deterioration, but not with increased mortality.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / psychology*
  • Capgras Syndrome / psychology*
  • Delusions / psychology*
  • Female
  • Hallucinations / psychology*
  • Humans
  • Longitudinal Studies
  • Male
  • Manuals as Topic
  • Neuropsychological Tests
  • Psychometrics
  • Psychotic Disorders / psychology*