Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 41, 93-98

Epitranscriptomics: Regulation of mRNA Metabolism Through Modifications

Affiliations
Review

Epitranscriptomics: Regulation of mRNA Metabolism Through Modifications

Eyal Peer et al. Curr Opin Chem Biol.

Abstract

Cellular RNAs can be modified post-transcriptionally with dynamic and reversible chemical modifications. These modifications can alter the structure and metabolism of mRNA, but only recent methodological and conceptual advances allowed systematic mapping and functional analysis to unfold the role they play in mRNA biology. Mapping the most common internal mRNA modification, N6-methyladenosine (m6A), paved the way for the deciphering of other types of mRNA modifications, such as N1-methyladenosine (m1A). RNA methylation provides dynamic regulation to the processing, export, translation and stability of mRNA molecules, thereby influencing fundamental biological and pathological processes such as differentiation, cellular response to stress and tumorigenesis. This review summarizes the key methods and the recent discoveries in the field of epitranscriptomics through the prism of post-transcriptional mRNA methylation in eukaryotes.

Similar articles

See all similar articles

Cited by 24 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback