Oral Cancer: Genetics and the Role of Precision Medicine

Dent Clin North Am. 2018 Jan;62(1):29-46. doi: 10.1016/j.cden.2017.08.002.

Abstract

Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world. OSCC patients are managed with surgery and/or chemoradiation. Prognoses and survival rates are dismal, however, and have not improved for more than 20 years. Recently, the concept of precision medicine was introduced, and the introduction of targeted therapeutics demonstrated promising outcomes. This article reviews the current understanding of initiation, progression, and metastasis of OSCC from both genetic and epigenetic perspectives. In addition, the applications and integration of omics technologies in biomarker discovery and drug development for treating OSCC are reviewed.

Keywords: Big data; Epigenetics; Malignant transformation; Omics technology; Oral cancer; Oral squamous cell carcinoma; Personalized medicine; Precision medicine.

Publication types

  • Review

MeSH terms

  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / therapy*
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / pathology
  • Disease Progression
  • Humans
  • Mouth Neoplasms / genetics*
  • Mouth Neoplasms / pathology*
  • Mouth Neoplasms / therapy*
  • Mutation
  • Precancerous Conditions / genetics
  • Precancerous Conditions / pathology
  • Precancerous Conditions / therapy
  • Precision Medicine*
  • Prognosis