Excretion of penicillins and cephalexin in bovine milk following intramammary administration

Food Addit Contam. 1989 Jan-Mar;6(1):79-89. doi: 10.1080/02652038909373741.

Abstract

The elimination into bovine milk of beta-lactam antibiotic residues (procaine penicillin G, cloxacillin, ampicillin, oxacillin, cephalexin) following intramammary administration of 10 preparations marketed in France was studied. The quantitative analysis of residues was carried out by a microbiological agar diffusion method using Bacillus stearothermophilus. Sensitivity ranged from 0.001 I.U./ml for procaine penicillin G and 0.001 micrograms/ml for ampicillin to 0.02 micrograms/ml for cephalexin. The mean periods of elimination on which withholding times are based were between four and seven milkings according to the drugs administered.

Publication types

  • Comparative Study

MeSH terms

  • Agar
  • Ampicillin / pharmacokinetics
  • Animals
  • Cattle
  • Cephalexin / administration & dosage
  • Cephalexin / pharmacokinetics*
  • Cloxacillin / pharmacokinetics
  • Diffusion
  • Female
  • Kinetics
  • Mammary Glands, Animal*
  • Milk / metabolism*
  • Oxacillin / pharmacokinetics
  • Penicillin G Procaine / pharmacokinetics
  • Penicillins / administration & dosage
  • Penicillins / pharmacokinetics*

Substances

  • Penicillins
  • Penicillin G Procaine
  • Ampicillin
  • Agar
  • Cloxacillin
  • Cephalexin
  • Oxacillin