Scavenger receptor class B type 1 regulates neuroblastoma cell proliferation, migration and invasion

Biochem Biophys Res Commun. 2018 Jan 1;495(1):614-620. doi: 10.1016/j.bbrc.2017.10.154. Epub 2017 Nov 9.

Abstract

Neuroblastoma (NB) is an extra cranial pediatric embryonal tumor most prevalent in children less than 1 year of age. NB accounts for 7% of all pediatric cancers but accounts for 15% of all childhood cancer deaths. Scavenger receptor class B type 1 (SR-B1), a mediator of cellular cholesterol uptake, is overexpressed in and have been linked to the aggressiveness of many cancers. Nevertheless, no studies have so far investigated the relationship between SR-B1 and NB. Elucidation of receptors that promote NB may pave the way for discovery of new therapeutic targets. Here we show that inhibition of SR-B1 reduced cell survival, migration and invasion, and cholesterol content in NB cell lines. Additionally analysis of SR-B1 levels in NB patient biopsies using the R2: Genomics Analysis and Visualization Platform showed that high SR-B1 expression correlated with decreased overall and event-free survival.

Keywords: Cholesterol metabolism; Neuroblastoma; Scavenger receptor class B type 1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Movement*
  • Cell Proliferation*
  • Cholesterol / metabolism*
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Neoplasm Invasiveness
  • Neuroblastoma / metabolism*
  • Neuroblastoma / mortality*
  • Neuroblastoma / pathology
  • Prevalence
  • Scavenger Receptors, Class C / metabolism*
  • Survival Rate
  • Texas / epidemiology

Substances

  • Scavenger Receptors, Class C
  • Cholesterol