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Review
. 2018 Feb;50:32-38.
doi: 10.1016/j.coi.2017.10.011. Epub 2017 Nov 10.

Recent Advances in Inflammasome Biology

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Free PMC article
Review

Recent Advances in Inflammasome Biology

David E Place et al. Curr Opin Immunol. .
Free PMC article

Abstract

The inflammasome is a complex of proteins that through the activity of caspase-1 and the downstream substrates gasdermin D, IL-1β, and IL-18 execute an inflammatory form of cell death termed pyroptosis. Activation of this complex often involves the adaptor protein ASC and upstream sensors including NLRP1, NLRP3, NLRC4, AIM2, and pyrin, which are activated by different stimuli including infectious agents and changes in cell homeostasis. Here we discuss new regulatory mechanisms that have been identified for the canonical inflammasomes, the most recently identified NLRP9b inflammasome, and the new gasdermin family of proteins that mediate pyroptosis and other forms of regulated cell death.

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