Abstract
We describe 3 patients with short bowel syndrome who had persistently elevated serum methylmalonic acid (MMA) levels while being treated for vitamin B12 deficiency. Following treatment for presumed small bowel bacterial overgrowth, MMA levels normalized. Among patients with short bowel syndrome, MMA levels may have limited specificity for vitamin B12 deficiency.
Keywords:
methylmalonic acid; short bowel syndrome; small bowel bacterial overgrowth; vitamin B12 deficiency.
Copyright © 2017 Elsevier Inc. All rights reserved.
Publication types
-
Case Reports
-
Research Support, N.I.H., Extramural
MeSH terms
-
Biomarkers / blood
-
Blind Loop Syndrome / blood
-
Blind Loop Syndrome / diagnosis*
-
Blind Loop Syndrome / etiology
-
Child
-
Child, Preschool
-
Diagnosis, Differential
-
Female
-
Humans
-
Male
-
Methylmalonic Acid / blood*
-
Short Bowel Syndrome / complications*
-
Short Bowel Syndrome / microbiology
-
Vitamin B 12 / therapeutic use
-
Vitamin B 12 Deficiency / blood
-
Vitamin B 12 Deficiency / diagnosis*
-
Vitamin B 12 Deficiency / drug therapy
-
Vitamin B 12 Deficiency / etiology
-
Vitamin B Complex / therapeutic use
Substances
-
Biomarkers
-
Vitamin B Complex
-
Methylmalonic Acid
-
Vitamin B 12