Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma

David G Mummy; Stanley J Kruger; Wei Zha; Ronald L Sorkness; Nizar N Jarjour; Mark L Schiebler; Loren C Denlinger; Michael D Evans; Sean B Fain

doi:10.1016/j.jaci.2017.10.016

Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma

J Allergy Clin Immunol. 2018 Mar;141(3):1140-1141.e4. doi: 10.1016/j.jaci.2017.10.016. Epub 2017 Nov 10.

Authors

David G Mummy¹, Stanley J Kruger², Wei Zha², Ronald L Sorkness³, Nizar N Jarjour⁴, Mark L Schiebler⁵, Loren C Denlinger⁴, Michael D Evans⁶, Sean B Fain⁷

Affiliations

¹ Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, Wis.
² Department of Medical Physics, University of Wisconsin - Madison, Madison, Wis.
³ Department of Pharmacy, University of Wisconsin - Madison, Madison, Wis; Department of Allergy, Pulmonary & Critical Care Medicine, University of Wisconsin - Madison, Madison, Wis; Department of Pediatrics, University of Wisconsin - Madison, Madison, Wis.
⁴ Department of Allergy, Pulmonary & Critical Care Medicine, University of Wisconsin - Madison, Madison, Wis.
⁵ Department of Radiology, University of Wisconsin - Madison, Madison, Wis.
⁶ Department of Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, Wis.
⁷ Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, Wis; Department of Medical Physics, University of Wisconsin - Madison, Madison, Wis; Department of Radiology, University of Wisconsin - Madison, Madison, Wis. Electronic address: sfain@wisc.edu.

Abstract

Ventilation defect percent (VDP) measured in asthmatics with hyperpolarized helium-3 MRI was more strongly associated with ED visits and hospitalizations due to asthma exacerbation than were conventional biomarkers of lung function and inflammation.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Asthma* / diagnostic imaging
Asthma* / physiopathology
Female
Helium / administration & dosage*
Humans
Isotopes / administration & dosage*
Lung* / diagnostic imaging
Lung* / physiopathology
Magnetic Resonance Imaging*
Male
Pulmonary Ventilation*

Substances

Isotopes
Helium
Helium-3

Abstract

Publication types

MeSH terms

Substances

Grants and funding