The Inhibitory Effects of Anthocyanin-Rich Sunrouge Tea on Pancreatic Lipase Activity

J Oleo Sci. 2017 Dec 1;66(12):1343-1348. doi: 10.5650/jos.ess17138. Epub 2017 Nov 13.

Abstract

This study investigated the in vitro and in vivo effects of Sunrouge (SR), which is an anthocyaninrich green tea. Hot and cold water extracts (CWEX) of Yabukita (YK; regular green tea), SR second crop (SR2), and SR third crop (SR3) were prepared. The 50% inhibitory concentrations for YK, SR2, and SR3 CWEXs against pancreatic lipase in vitro were 12.3±2.8, 6.2±0.3, and 4.0±1.1 mg/mL, respectively. Epigallocatechin gallate (EGCG) accounted for 4.3%, 6.0%, and 6.3% of YK, SR2, and SR3 CWEXs, respectively. SR2 had the highest anthocyanin content of these three samples. In vivo, the increase in the plasma triacylglycerol (TG) concentration following oral administration of oil to mice was significantly suppressed at 60 and 120 min in animals treated with SR2. No significant differences were observed between the plasma TG concentration in the YK and control groups. These results suggested that concomitant administration of SR with oil may suppress lipid absorption and that EGCG may exert this effect.

Keywords: epigallocatechin gallate; functional food; green tea; lipid; obesity.

MeSH terms

  • Administration, Oral
  • Animals
  • Anthocyanins / administration & dosage
  • Anthocyanins / isolation & purification
  • Anthocyanins / pharmacology*
  • Catechin / administration & dosage
  • Catechin / analogs & derivatives
  • Catechin / isolation & purification
  • Catechin / pharmacology
  • Enzyme Activation / drug effects*
  • In Vitro Techniques
  • Lipase / metabolism*
  • Male
  • Mice, Inbred ICR
  • Pancreas / enzymology*
  • Plant Extracts / administration & dosage
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Tea / chemistry*
  • Triglycerides / blood
  • Water

Substances

  • Anthocyanins
  • Plant Extracts
  • Tea
  • Triglycerides
  • Water
  • Catechin
  • epigallocatechin gallate
  • Lipase