Mechanisms and function of autophagy in intestinal disease

Autophagy. 2018;14(2):216-220. doi: 10.1080/15548627.2017.1389358. Epub 2018 Jan 29.


The discovery of numerous genetic variants in the human genome that are associated with inflammatory bowel disease (IBD) has revealed critical pathways that play important roles in intestinal homeostasis. These genetic studies have identified a critical role for macroautophagy/autophagy and more recently, lysosomal function, in maintaining the intestinal barrier and mucosal homeostasis. This review highlights recent work on the functional characterization of IBD-associated human genetic variants in cell type-specific functions for autophagy.

Keywords: ATG16L1; Crohn disease; GPR65; IBD; autophagy; inflammation; lysosomal dysfunction; mitophagy.

Publication types

  • Review

MeSH terms

  • Animals
  • Autophagy / genetics
  • Autophagy / immunology*
  • Autophagy-Related Proteins / genetics
  • Autophagy-Related Proteins / metabolism
  • Crohn Disease / genetics
  • Crohn Disease / immunology
  • Cytokines / metabolism
  • Genetic Predisposition to Disease
  • Humans
  • Inflammatory Bowel Diseases / genetics
  • Inflammatory Bowel Diseases / immunology*
  • Intestinal Mucosa / immunology
  • Lysosomes / metabolism*
  • Mice
  • Reactive Oxygen Species / metabolism


  • Autophagy-Related Proteins
  • Cytokines
  • Reactive Oxygen Species