Association of LRRK2 Haplotype With Age at Onset in Parkinson Disease

JAMA Neurol. 2018 Jan 1;75(1):127-128. doi: 10.1001/jamaneurol.2017.3363.

Bin Xiao¹, Xiao Deng¹, Ebonne Yu-Lin Ng¹, John Carson Allen Jr², Shen-Yang Lim³, Azlina Ahmad-Annuar⁴, Eng-King Tan^{1

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¹ National Neuroscience Institute, Singapore.
² Centre for Quantitative Medicine, Duke-National University of Singapore Medical School, Singapore.
³ Divisions of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
⁴ Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
⁵ Department of Neurology, Singapore General Hospital, Singapore.
⁶ Duke-National University of Singapore Graduate Medical School, Singapore.

Abstract

This study examines the effect of LRRK2 risk variants on the age at onset of Parkinson disease.