A Crash Course in Calcium Channels

ACS Chem Neurosci. 2017 Dec 20;8(12):2583-2585. doi: 10.1021/acschemneuro.7b00415. Epub 2017 Nov 13.

Abstract

Much progress has been made in understanding the molecular physiology and pharmacology of calcium channels. Recently, there have been tremendous advances in learning about calcium channel structure and function through crystallography and cryo-electron microscopy studies. Here, I will give an overview of our knowledge about calcium channels, and highlight two recent studies that give important insights into calcium channel structure.

Keywords: Calcium channels; pharmacology; physiology.

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Calcium / chemistry*
  • Calcium Channels / chemistry*
  • Calcium Channels / metabolism
  • Calcium Channels / ultrastructure*
  • Humans
  • Models, Chemical*
  • Models, Molecular*
  • Protein Binding
  • Protein Conformation
  • Structure-Activity Relationship

Substances

  • Calcium Channels
  • Calcium