The use of anticoagulation in the prevention of strokes due to atrial fibrillation or the treatment of venous thromboembolic disease has been on the rise. With the advent and proliferation of direct oral anticoagulation medications, the management of anticoagulation reversal has become increasingly complex, especially when urgent or emergent reversal is required. This review details the commonly used parenteral and oral anticoagulants, the treatment strategies necessary for their reversal, and therapies still in development.
Keywords: Andexanet alfa; Anticoagulation reversal; Aripazine; Direct oral anticoagulants; Idarucizumab; Protamine; Prothrombin complex concentrate; Warfarin.
Copyright © 2017 Elsevier Inc. All rights reserved.