Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench

J Ethnopharmacol. 2018 Mar 1;213:132-137. doi: 10.1016/j.jep.2017.11.013. Epub 2017 Nov 11.


Ethnopharmacological relevance: Meadowsweet (Filipendula ulmaria (L.) Maxim.) and dropwort (Filipendula vulgaris Moench) are herbaceous perennials employed in folk medicine for their antirheumatic, antipyretic and anti-ulcer properties.

Aim of the study: To assess ethnomedicinal claims through investigation of antioxidant, anti-inflammatory and gastroprotective effects of F. ulmaria and F. vulgaris lyophilized flower infusions (LFIs) as well as the F. vulgaris isolated flavonoids spiraeoside, kaempferol 4'-O-glucoside, astragalin 2'-O-gallate, mixture of hyperoside 2'-O-gallate and isoquercitrin 2'-O-gallate, and a tannin tellimagrandin II.

Materials and methods: Free radical scavenging activity of the tested samples was determined by examining their ability to neutralize DPPH and OH radicals in vitro, whereas reducing properties were assessed in Ferric Reducing Antioxidant Power (FRAP) assay. Anti-inflammatory activity was studied ex vivo in human platelets by monitoring the effect on eicosanoid biosynthesis. Gastroprotective action was estimated in animal model of acute gastric injury induced by ethanol.

Results: LFIs and spiraeoside exerted activities comparable to those of positive control in DPPH-radical scavenging and FRAP antioxidant assays, whereas notable hydroxyl radical scavenging ability was demonstrated only for spiraeoside (IC50 = 5.1μg/mL). Among tested samples, astragalin 2″-O-gallate (IC50 = 141.1μg/mL) and spiraeoside (IC50 = 4.69μg/mL) the most markedly inhibited production of pro-inflammatory prostaglandin E2 and 12(S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid in human platelets, respectively. Examination of LFIs (100-300mg/kg, p.o.) gastroprotective action in rats revealed their capacity to preserve mucosal integrity. In addition, spiraeoside (50mg/kg, p.o.) and tellimagrandin II (40mg/kg, p.o.) showed ulcer preventive ability.

Conclusion: Current study supports documented traditional use of investigated herbs and indicates that flavonoid and tannin components are partially responsible for the demonstrated pharmacological activities.

Keywords: Anti-inflammatory; Antioxidant; Dropwort; Filipendula; Gastroprotective; Meadowsweet.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use*
  • Anti-Ulcer Agents / therapeutic use*
  • Antioxidants / therapeutic use*
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism
  • Eicosanoids / metabolism
  • Ethanol
  • Filipendula*
  • Flowers
  • Humans
  • Male
  • Phytotherapy
  • Plant Extracts / therapeutic use*
  • Rats, Wistar
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / drug therapy


  • Anti-Inflammatory Agents
  • Anti-Ulcer Agents
  • Antioxidants
  • Eicosanoids
  • Plant Extracts
  • Ethanol