Galectin-3: mediator of microglia responses in injured brain

Drug Discov Today. 2018 Feb;23(2):375-381. doi: 10.1016/j.drudis.2017.11.004. Epub 2017 Nov 10.


Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / metabolism*
  • Brain Diseases / metabolism*
  • Galectin 3 / metabolism*
  • Humans
  • Microglia / metabolism*


  • Galectin 3