Objective: Waist-to-height ratio (WHtR), a measurement of the distribution of body fat, correlated with abdominal obesity indicating that it might be a better predictor of cardiovascular risk and metabolic disease. We, therefore, evaluated optimal WHtR cutoff points according to the risk of framingham risk score (FRS) and metabolic syndrome (MS) in Chinese. Methods: The subjects were from China National Diabetes and Metabolic Disorders Survey during 2007-2008. Receiver operating characteristic analysis was used to examine the optimal cutoff values of WHtR according to the risk of FRS and MS. Results: A total of 27 820 women and 18 419 men were included in the evaluation. The average age was (45.0±13.7) years. The proportions of FRS ≥10% and MS increased with WHtR both in men and women. The cutoff points of WHtR for the risk of FRS ≥10% and MS were 0.51, 0.52 in men, and 0.52, 0.53 in women, respectively. When FRS ≥10% and MS were taken into consideration with a certain weights, the pooled cutoffs of WHtR were 0.51 in men, and 0.53 in women, respectively. By using the similar method, the optimized cutoff points were 0.52, 0.51, 0.50 for men and 0.51, 0.53, 0.54 for women in age group 20-39, 40-59 and ≥60 years, respectively. Conclusions: The optimal cutoffs of WHtR are 0.51 in men, and 0.53 in women for FRS≥10% in combination with MS indicating that this WHtR cutoff points might be used as indexes to evaluate obesity and risk of obesity-related diseases.
目的： 根据弗雷明汉10年心血管风险评分(framingham risk score, FRS)和代谢综合征(metabolic syndrome, MS)风险，计算中国人群腰高比(waist－to－height ratio, WHtR)最佳切点。 方法： 采用ROC曲线根据FRS和MS患病风险，计算WHtR最佳切点，并依据FRS≥10%和MS患病率所占权重来对诊断切点进行合并，得出最终WHtR切点。 结果： 本研究共纳入46 239名受试者，年龄(45.0±13.7)岁，其中男性18 419名，女性27 820名。随着WHtR的增加，男性和女性人群中FRS≥10%和MS患病风险上升。分别以FRS≥10%和MS作为观察终点，男性对应的最佳WHtR切点分别为0.51，0.52；女性为0.52，0.53。权重后WHtR最佳切点男性为0.51，女性为0.53。使用同样方法来确定各年龄组WHtR最佳切点，男性20～39岁组、40～59岁组、≥60岁组分别为0.52，0.51，0.50；女性则分别为0.51，0.53，0.54。 结论： 中国男性WHtR最佳切点为0.51；女性为0.53。建议推广WHtR作为评估肥胖及肥胖带来心血管及代谢性疾病风险的手段。.
Keywords: Framingham risk score; Metabolic syndrome; Waist-to-height ratio.