Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
, 7 (1), 15491

Changing Trends in the Prevalence of H. Pylori Infection in Japan (1908-2003): A Systematic Review and Meta-Regression Analysis of 170,752 Individuals

Affiliations
Meta-Analysis

Changing Trends in the Prevalence of H. Pylori Infection in Japan (1908-2003): A Systematic Review and Meta-Regression Analysis of 170,752 Individuals

Chaochen Wang et al. Sci Rep.

Abstract

Changing trends in the prevalence of H. pylori infection in the general population over time are thought to be the main driving force behind the declining gastric cancer mortality in Japan. However, whether the prevalence of H. pylori infection itself shows a birth-cohort pattern needs to be corroborated. We performed a systematic review of studies that reported the prevalence of H. pylori infection among Japanese individuals. Meta-regression was conducted in the framework of a generalized additive mixed model (GAMM) to account for heterogeneity in the prevalence of H. pylori infection as a function of birth year. The prevalence of H. pylori infection confirmed a clear birth cohort pattern: the predicted prevalence (%, 95% CI) was 60.9 (56.3-65.4), 65.9 (63.9-67.9), 67.4 (66.0-68.7), 64.1 (63.1-65.1), 59.1 (58.2-60.0), 49.1 (49.0-49.2), 34.9 (34.0-35.8), 24.6 (23.5-25.8), 15.6 (14.0-17.3), and 6.6 (4.8-8.9) among those who were born in the year 1910, 1920, 1930, 1940, 1950, 1960, 1970, 1980, 1990, and 2000, respectively. The present study demonstrated a clear birth-cohort pattern of H. pylori infection in the Japanese population. The decreased prevalence of H. pylori infection in successive generations should be weighed in future gastric cancer control programs.

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
PRISMA flow chart of study selection.
Figure 2
Figure 2
Multivariable adjusted prevalence of H. pylori infection in Japanese by birth year from year of 1908–2003.

Similar articles

See all similar articles

Cited by 4 PubMed Central articles

References

    1. Cover TL, Blaser MJ. Helicobacter pylori in health and disease. Gastroenterol. 2009;136:1863–1873. doi: 10.1053/j.gastro.2009.01.073. - DOI - PMC - PubMed
    1. Inoue M. Changing epidemiology of Helicobacter pylori in Japan. Gastric Cancer. 2017;20:3–7. doi: 10.1007/s10120-016-0658-5. - DOI - PubMed
    1. Asaka M, et al. Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterol. 1992;102:760–766. doi: 10.1016/0016-5085(92)90156-S. - DOI - PubMed
    1. Ueda J, et al. Prevalence of Helicobacter pylori Infection by Birth Year and Geographic Area in Japan. Helicobacter. 2014;19:105–110. doi: 10.1111/hel.12110. - DOI - PubMed
    1. Shibata K, et al. Relation of Helicobacter pylori infection and lifestyle to the risk of chronic atrophic gastritis: A cross-sectional study in Japan. J Epidemiol. 2002;12:105–111. doi: 10.2188/jea.12.105. - DOI - PubMed

Publication types

Feedback