Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 28 (4), 1568-1578

Morphological Classification of Intraductal Papillary Neoplasm of the Bile Duct

Affiliations

Morphological Classification of Intraductal Papillary Neoplasm of the Bile Duct

Shihong Ying et al. Eur Radiol.

Abstract

Objectives: To investigate the morphological classification of intraductal papillary neoplasm of the bile duct (IPNB), as well as morphological differences between IPNB without mucin secretion (IPNB-NM) and IPNB with mucin secretion (IPMN-B).

Methods: Eighty-one patients with IPNB were retrospectively analysed. Imaging examinations included computed tomography (CT), magnetic resonance imaging (MRI), gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI and positron emission tomography-computed tomography (PET-CT). According to the morphology of tumours and extent of bile duct dilations, IPNB was classified into seven types: I, upstream-ductectatic type; II, typical type; III, superficial-spreading type; IV, no-mass-forming type; V, intrahepatic-cystic type; VI, extrahepatic-cystic type; and VII, infiltrating type.

Results: Thirteen IPNB-NM patients comprised type I (11 cases), type II (1 case) and type VII (1 case); 68 IPMN-B patients comprised type I (2 cases), type II (30 cases), type III (6 cases), type IV (11 cases), type V (13 cases), type VI (2 cases) and type VII (4 cases). Bile duct dilations were more severe in IPMN-B than in IPNB-NM. PET-CT and Gd-EOB-DTPA-enhanced MRI clearly demonstrated the extension of infiltrating IPNB.

Conclusions: IPNB can be classified into seven morphological types. IPNB-NM and IPMN-B have different morphological features.

Key points: • IPNB can be classified into seven morphological types. • IPNB-NM and IPMN-B have different morphological features. • Enhanced CT and MRI can display different types of IPNB. • Morphological classification of IPNB facilitates management of the disease.

Keywords: Bile duct; Cholangiocarcinoma; Computed tomography; Intraductal papillary neoplasm; Magnetic resonance imaging.

Similar articles

See all similar articles

Cited by 2 articles

References

    1. Hepatology. 2012 Oct;56(4):1352-60 - PubMed
    1. Histol Histopathol. 2014 Jan;29(1):1-10 - PubMed
    1. J Hepatobiliary Pancreat Sci. 2010 May;17 (3):223-9 - PubMed
    1. Clin Nucl Med. 2010 Feb;35(2):83-5 - PubMed
    1. World J Gastroenterol. 2015 Jul 7;21(25):7824-33 - PubMed

MeSH terms

Substances

LinkOut - more resources

Feedback