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. 2018 Jan 4;46(D1):D8-D13.
doi: 10.1093/nar/gkx1095.

Database Resources of the National Center for Biotechnology Information

Free PMC article

Database Resources of the National Center for Biotechnology Information

NCBI Resource Coordinators. Nucleic Acids Res. .
Free PMC article


The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. The Entrez system provides search and retrieval operations for most of these data from 39 distinct databases. The E-utilities serve as the programming interface for the Entrez system. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. New resources released in the past year include PubMed Data Management, RefSeq Functional Elements, genome data download, variation services API, Magic-BLAST, QuickBLASTp, and Identical Protein Groups. Resources that were updated in the past year include the genome data viewer, a human genome resources page, Gene, virus variation, OSIRIS, and PubChem. All of these resources can be accessed through the NCBI home page at


Figure 1.
Figure 1.
Graphical Depiction of Selected Entrez Links. Each cell in the matrix is shaded according to the log (base 10) of the number of records in the source database (rows) that have an Entrez link to the destination database (columns). Diagonal cells represent computational links (e.g. pubmed related articles) and off-diagonal cells assert biological relationships (e.g. nuccore to taxonomy). The matrix is not diagonal because an individual record in a source database may have many links to a destination database (e.g. genome to protein).
Figure 2.
Figure 2.
Expression profile data for human TRIM15 (gene ID 89870) as displayed on the Gene full report (

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