Objective: To investigate the effect of triple therapy with aspirin, prednisone and Elevit in patients with unexplained recurrent early pregnancy loss. Methods: From January 1, 2013 to December 31, 2016, a total of 353 women of childbearing age were enrolled in Peking Union Medical College Hospital, including blood, urine and vaginal swabs. One hundred and fifty-five patients were observed normal results of blood test, urine test and vaginal swabs. According to the treatment regimen, 155 patients were divided into two groups, 89 patients (57.42%) treated with (aspirin, prednisone, and Elevit) as experimental group, and the other 66 cases (42.58%) taking folic acid as control group. The fetal bud, fetal heart and neck hyaline layer thickness were examined by ultrasonography at 12 weeks. Visible fetal bud, fetal heart, and nuchal translucency thickness <0.3 cm were used as indicators of successful treatment. t test and χ(2) test were used to analyze and compare the statistical significance of the differences between the two groups of patients, and the Logistic method was used to analyze the data and observe the effect of medication. Results: There were 67 patients successfully treated in the experimental group, the successful rate was 83.75% (67/80), and 33 patients in the control group were successfully treated, the successful rate was 54.10% (33/61). There were significant statistical differences in two groups (P<0.05). Conclusion: The effect of triple therapy with aspirin, prednisone and Elevit in patients with unexplained recurrent early pregnancy loss is significant.
目的： 探讨阿司匹林、泼尼松与爱乐维联合用药在治疗不明原因早期复发性自然流产中的效果。 方法： 收集2013年1月1日至2016年12月31日于北京协和医院就诊育龄期妇女，共353例。纳入其中血、尿、阴拭子等项目检查结果均为正常的155例患者为观察对象。将155例患者根据治疗用药分组，三联(阿司匹林、泼尼松、爱乐维)用药治疗的89例(57.42%)患者作为试验组，将服用叶酸的66例(42.58%)患者作为对照组；经超声检查孕12周时的胎芽胎心与颈项透明层厚度，将可见胎芽胎心并且颈项透明层厚度<0.3 cm作为治疗成功的指标。差异统计学意义检验采用t检验与χ(2)检验，分析比较两组患者之间各项指标差异的统计学意义，并使用Logistic方法对数据进行校正分析，观察用药的效果。 结果： 试验组患者中治疗成功67例，成功率为83.75%(67/80)；对照组患者中治疗成功33例，成功率为54.10%(33/61)，两组比较差异有统计学意义(P<0.05)。 结论： 针对不明原因早期复发性自然流产的患者，治疗中使用三联用药具有显著的治疗效果，可以降低患者妊娠早期的流产率。.
Keywords: Aspirin; Early recurrent spontaneous abortion; Elevit; Prednisone.