Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018;18(5):667-674.
doi: 10.2174/1871520617666171113121246.

Ganoderma Lucidum Polysaccharides as An Anti-cancer Agent

Affiliations
Free PMC article
Review

Ganoderma Lucidum Polysaccharides as An Anti-cancer Agent

Didem Sohretoglu et al. Anticancer Agents Med Chem. .
Free PMC article

Abstract

The mushroom Ganoderma lucidum (G. lucidum) has been used for centuries in Asian countries to treat various diseases and to promote health and longevity. Clinical studies have shown beneficial effects of G. lucidum as an alternative adjuvant therapy in cancer patients without obvious toxicity. G. lucidum polysaccharides (GLP) is the main bioactive component in the water soluble extracts of this mushroom. Evidence from in vitro and in vivo studies has demonstrated that GLP possesses potential anticancer activity through immunomodulatory, anti-proliferative, pro-apoptotic, anti-metastatic and anti-angiogenic effects. Here, we briefly summarize these anticancer effects of GLP and the underlying mechanisms.

Keywords: Ganoderma lucidum polysaccharides; Reishi; anti-angiogenic; anti-cancer; anti-metastatic; anti-proliferative; immunomodulatory; pro-apoptotic..

Conflict of interest statement

CONFLICT OF INTEREST

No potential conflicts of interest were disclosed.

Figures

Fig 1
Fig 1
Cancer-related effects of Gonaderma lucidium polysaccharides. Arrows represent activation, whereas bars represent inhibition.
Fig 2
Fig 2
Mechanisms of immunomodulatory action of Gonaderma lucidium polysaccharides. ↑: increasing or activating.
Fig 3
Fig 3
Signaling pathways involved in anti-proliferative and pro-apoptotic effects of Gonaderma lucidium polysaccharides on tumor cells. Arrows represent activation, whereas bars represent inhibition.
Fig 4
Fig 4
Signaling pathways involved in anti-metastatic effect of Gonaderma lucidium polysaccharides. Arrows represent activation, whereas bars represent inhibition.

Similar articles

See all similar articles

Cited by 4 articles

Publication types

MeSH terms

Substances

Feedback