Evaluation of Antioxidative and Diabetes-Preventive Properties of an Ancient Grain, KAMUT ® Khorasan Wheat, in Healthy Volunteers

Eur J Nutr. 2019 Feb;58(1):151-161. doi: 10.1007/s00394-017-1579-8. Epub 2017 Nov 16.


Purpose: Recently, there was an increasing interest on the use of ancient grains because of their better health-related composition. The aim of this study was to evaluate in healthy human subjects the antioxidative and diabetes-preventive properties of ancient KAMUT® khorasan wheat compared to modern wheat.

Methods: The study was a randomized, non-blind, parallel arm study where the biochemical parameters of volunteers with a diet based on organic whole grain KAMUT® khorasan products, as the only source of cereal products were compared to a similar replacement diet based on organic whole grain modern durum wheat products. A total of 30 healthy volunteers were recruited and the intervention period lasted 16 weeks. Blood analyses were performed before and after the diet intervention. The effect of KAMUT® khorasan products on biochemical parameters was analyzed by multiple quantile regression adjusted for age, sex, physical activity and BMI compared to data at baseline.

Results: Subjects receiving KAMUT® khorasan products showed a significantly greater decrease of fat mass (b = 3.7%; CI 1.6-5.5; p = 0.042), insulin (b = 2.4 µU/ml; CI 0.2-4.2; p = 0.036) and a significant increase of DHA (b = - 0.52%; CI - 1.1 to - 0.12; p = 0.021).

Conclusions: Our study provides evidence that a substitution diet with KAMUT® khorasan wheat products can reduce some markers associated to the development of type-2 diabetes compared to a diet of modern wheat.

Keywords: Ancient wheat.; Antioxidant properties; DHA; Diabetes risk factors; KAMUT® khorasan wheat; Selenium.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antioxidants / pharmacology*
  • Diabetes Mellitus, Type 2 / prevention & control*
  • Edible Grain
  • Female
  • Healthy Volunteers
  • Humans
  • Male
  • Oxidative Stress / drug effects*
  • Pilot Projects
  • Reference Values
  • Triticum*


  • Antioxidants