Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 61 (2), 444-452

Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?

Affiliations
Review

Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?

Ian Churcher. J Med Chem.

Abstract

Targeted protein degradation, using bifunctional small molecules (Protacs) to remove specific proteins from within cells, has emerged as a novel drug discovery strategy with the potential to offer therapeutic interventions not achievable with existing approaches. In this Perspective, the brief history of the field is surveyed from a drug discovery perspective with a focus on the key advances in knowledge which have led to the definition and exemplification of protein degradation concepts and their resulting applications to medicine discovery. The approach has the potential to bring disruptive change to drug discovery; the many potential advantages and outstanding challenges which lie ahead of this technology are discussed.

Similar articles

See all similar articles

Cited by 35 articles

See all "Cited by" articles

MeSH terms

Substances

LinkOut - more resources

Feedback