Alveolar soft part sarcoma with multiple brain and lung metastases in pregnancy: A case report and literature review

Medicine (Baltimore). 2017 Nov;96(46):e8790. doi: 10.1097/MD.0000000000008790.


Rational: Alveolar soft part sarcomas (ASPSs) with multiple brain metastases in pregnancy is a rare entity.

Patient concerns: We report our experience with a 19-year-old pregnant woman who presented with intermittent headaches and vomiting at 38 weeks gestation.

Diagnoses: The patient was initially diagnosed as brain metastasis according to computed tomography and magnetic resonance imaging (MRI) imaging.

Interventions: Cesarean section and craniotomy (complete resection of both brain metastatic lesions) was performed sequentially.

Outcomes: A healthy baby girl was delivered safely and no neonatal malformations were found. Histological analysis confirmed the diagnosis of ASPS. Follow-up MRI performed 10 months after surgery revealed no residual tumor or signs of recurrence.

Lessons: We report a case of ASPS with multiple brain and lung metastases in a pregnant woman. We recommend timely MRI examination for diagnosis and have discussed the approach to the treatment of pregnant women with brain metastasis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Brain Neoplasms / secondary*
  • Brain Neoplasms / surgery
  • Cesarean Section
  • Female
  • Humans
  • Live Birth
  • Lung Neoplasms / secondary*
  • Lung Neoplasms / surgery
  • Pregnancy
  • Pregnancy Complications, Neoplastic / pathology*
  • Pregnancy Complications, Neoplastic / surgery
  • Sarcoma, Alveolar Soft Part / secondary*
  • Sarcoma, Alveolar Soft Part / surgery
  • Treatment Outcome
  • Young Adult