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, 3 (2), 174-7

Hepatocyte Function and Extracellular Matrix Geometry: Long-Term Culture in a Sandwich Configuration

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Hepatocyte Function and Extracellular Matrix Geometry: Long-Term Culture in a Sandwich Configuration

J C Dunn et al. FASEB J.

Erratum in

  • FASEB J 1989 May;3(7):1873

Abstract

Adult rat hepatocytes cultured in a collagen sandwich system maintained normal morphology and a physiological rate of albumin secretion for at least 42 days. Hepatocytes cultured on a single layer of collagen gel essentially ceased albumin secretion within 1 wk but could recover function with the overlay of a second layer of collagen gel. This culture configuration more closely mimics the hepatocytes' in vivo environment and provides a simple method for their long-term maintenance.

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