Dynamics under the Telomeric Bridge

Sabrina Pisano; Eric Gilson; Marie-Josèphe Giraud-Panis

doi:10.1016/j.molcel.2017.11.005

Dynamics under the Telomeric Bridge

Mol Cell. 2017 Nov 16;68(4):643-644. doi: 10.1016/j.molcel.2017.11.005.

Authors

Sabrina Pisano¹, Eric Gilson², Marie-Josèphe Giraud-Panis³

Affiliations

¹ Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR7284/INSERM U1081 Université Côte d'Azur, 06107 Nice, France.
² Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR7284/INSERM U1081 Université Côte d'Azur, 06107 Nice, France; International Laboratory of Hematology and Cancer, Shanghai Jiao Tong University School of Medicine/Ruijin Hospital/CNRS/INSERM/Nice University, Shanghai Ruijin Hospital, Shanghai 200025, P.R. China; Department of Genetics, CHU, 06003 Nice, France.
³ Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR7284/INSERM U1081 Université Côte d'Azur, 06107 Nice, France. Electronic address: Marie-Josephe.GIRAUD-PANIS@unice.fr.

PMID: 29149592
DOI: 10.1016/j.molcel.2017.11.005

Abstract

In this issue of Molecular Cell, Kim et al. (2017) have studied the structure and organization of the shelterin protein complex protecting telomeres in Schizosaccharomyces pombe and humans and discovered an allosteric structural transition that drives the formation of the shelterin complex and participates in telomere length regulation.

Publication types

Review

MeSH terms

Humans
Schizosaccharomyces
Shelterin Complex
Telomere / genetics
Telomere / metabolism*
Telomere Homeostasis / physiology*
Telomere-Binding Proteins / genetics
Telomere-Binding Proteins / metabolism*

Substances

Shelterin Complex
Telomere-Binding Proteins