AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging

Trends Endocrinol Metab. 2018 Jan;29(1):8-17. doi: 10.1016/j.tem.2017.10.009. Epub 2017 Nov 14.

Abstract

The NLRP3 inflammasome has recently emerged as an unexpected marker of stress and metabolic risk and has also been implicated in the development of major aging-related diseases such as gout, type 2 diabetes, obesity, cancer, and neurodegenerative and cardiovascular disorders. Several pathways regulating the NLRP3 inflammasome are currently being studied, but how the NLRP3 inflammasome is regulated remains unknown. AMP-activated protein kinase (AMPK), a central regulator of multiple metabolic pathways involved in the pathophysiology of aging and age-related diseases, has emerged as an important integrator of signals controlling inflammation including the inflammasome. In this Opinion article, we show that several AMPK-dependent pathways regulate NLRP3 inflammasome activation during aging, suggesting NLRP3 as a potential pharmacological target in age-related diseases.

Keywords: AMPK; NLRP3 inflammasome; aging; autophagy.

Publication types

  • Review

MeSH terms

  • AMP-Activated Protein Kinases* / immunology
  • AMP-Activated Protein Kinases* / metabolism
  • Aging* / immunology
  • Aging* / metabolism
  • Humans
  • Inflammasomes* / immunology
  • Inflammasomes* / metabolism
  • NLR Family, Pyrin Domain-Containing 3 Protein* / immunology
  • NLR Family, Pyrin Domain-Containing 3 Protein* / metabolism

Substances

  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • AMP-Activated Protein Kinases