Translation initiation factors and their relevance in cancer

Curr Opin Genet Dev. 2018 Feb;48:82-88. doi: 10.1016/j.gde.2017.11.001. Epub 2017 Nov 16.

Abstract

Deregulation of several translation initiation factors occurs in numerous types of cancers. Translation initiation factors are not merely ancillary players in cancer development and progression, but rather, they are key participants in cellular transformation and tumor development. In fact, the altered expression of translation initiation factors is involved in cancer cell survival, metastasis and tumor angiogenesis. Although the exact mechanisms remain to be fully characterized, translation initiation factors comprise novel targets for pharmacologic intervention. Here we review the most recently established roles of initiation factors in cancer development and progression, as well as unique methods used to study translational regulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carcinogenesis
  • Cell Transformation, Neoplastic
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasms / metabolism*
  • Peptide Initiation Factors / genetics
  • Peptide Initiation Factors / metabolism*

Substances

  • Peptide Initiation Factors