Optimization of peptide-based polyagonists for treatment of diabetes and obesity

Bioorg Med Chem. 2018 Jun 1;26(10):2873-2881. doi: 10.1016/j.bmc.2017.10.047. Epub 2017 Nov 2.
No abstract available

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Drug Discovery / methods*
  • Gastric Inhibitory Polypeptide / agonists*
  • Gastric Inhibitory Polypeptide / metabolism
  • Glucagon / agonists*
  • Glucagon / metabolism
  • Glucagon-Like Peptide 1 / agonists*
  • Glucagon-Like Peptide 1 / metabolism
  • Humans
  • Obesity / drug therapy*
  • Obesity / metabolism
  • Peptides / chemistry
  • Peptides / pharmacology*
  • Peptides / therapeutic use

Substances

  • Peptides
  • Gastric Inhibitory Polypeptide
  • Glucagon-Like Peptide 1
  • Glucagon