Allograft Bone: What Is the Role of Platelet-Derived Growth Factor in Hindfoot and Ankle Fusions

Clin Podiatr Med Surg. 2018 Jan;35(1):37-52. doi: 10.1016/j.cpm.2017.08.008. Epub 2017 Oct 19.


Arthrodesis of the ankle or foot is a common procedure for chronic pain and disability. Nonunion remains a prevalent complication among arthrodesis procedures. Some patients present with an inherent risk of developing a nonunion. Allograft biologics have gained popularity in an effort to reduce complications such as nonunion. Various biologics bring unique properties while maintaining a singular purpose. Platelet-derived growth factor (PDGF) may be introduced into a fusion site to facilitate healthy bony consolidation. The purpose of this article is to review the benefits and modalities of PDGF and how it can improve patient outcomes in ankle and hindfoot fusions.

Keywords: Allograft; Ankle; Bone graft; Fusion; Hindfoot; PDGF; Platelet-derived growth factor.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Allografts
  • Ankle Joint / surgery*
  • Arthrodesis / methods*
  • Biocompatible Materials
  • Biological Products / therapeutic use
  • Bone Transplantation
  • Calcium Phosphates / therapeutic use
  • Female
  • Foot Joints / surgery*
  • Fractures, Ununited / therapy*
  • Humans
  • Male
  • Middle Aged
  • Platelet-Derived Growth Factor / physiology
  • Platelet-Derived Growth Factor / therapeutic use*
  • Tissue Scaffolds


  • Biocompatible Materials
  • Biological Products
  • Calcium Phosphates
  • Platelet-Derived Growth Factor
  • beta-tricalcium phosphate