The main aim of this review was to evaluate the association between physical activity and retinopathy. Secondary aims included evaluating the association between sedentary behavior and retinopathy, and evaluating the association between physical activity/sedentary behavior on health outcomes among patients with existing retinopathy. Twenty-one articles met our criteria for inclusion in this review. Among the 19 studies evaluating the main aim (physical activity and retinopathy), 53% (n = 10/19) demonstrated evidence of a favorable (inverse) association between physical activity and retinopathy, 42% (n = 8/19) reported a null association physical activity and retinopathy, and 5% (n = 1/19) presented evidence for a detrimental association between physical activity and retinopathy. Regarding the secondary aims, one study demonstrated a detrimental association between sedentary behavior and retinopathy. Similarly, one study demonstrated that physical activity was protective against early mortality among those with mild retinopathy. This review identifies an 'indeterminate' association between physical activity and retinopathy. Too few studies evaluated the association between sedentary behavior and retinopathy or the effects of physical activity on health outcomes among those with existing retinopathy.
Keywords: Bias; diabetes; epidemiology; exercise; mortality; retinopathy.