Recurrent diabetes insipidus associated with pregnancy: pathophysiology and therapy

Obstet Gynecol. 1989 Mar;73(3 Pt 2):462-4.


Diabetes insipidus during pregnancy is an uncommon medical problem. We present a woman who developed transient central diabetes insipidus during two successive pregnancies. A water deprivation study with plasma arginine vasopressin concentrations confirmed the diagnosis and established the efficacy of 1-desamino-8-d-arginine-vasopressin (dDAVP). The patient was then successfully and safely treated through the second pregnancy with dDAVP.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Arginine Vasopressin / blood
  • Deamino Arginine Vasopressin / therapeutic use*
  • Diabetes Insipidus* / drug therapy
  • Diabetes Insipidus* / physiopathology
  • Female
  • Humans
  • Osmolar Concentration
  • Pregnancy
  • Pregnancy Complications* / drug therapy
  • Pregnancy Complications* / physiopathology
  • Recurrence
  • Water Deprivation
  • Water-Electrolyte Balance


  • Arginine Vasopressin
  • Deamino Arginine Vasopressin