Comparison of quantitative regional ventilation-weighted fourier decomposition MRI with dynamic fluorinated gas washout MRI and lung function testing in COPD patients

Till F Kaireit; Marcel Gutberlet; Andreas Voskrebenzev; Julia Freise; Tobias Welte; Jens M Hohlfeld; Frank Wacker; Jens Vogel-Claussen

doi:10.1002/jmri.25902

Comparison of quantitative regional ventilation-weighted fourier decomposition MRI with dynamic fluorinated gas washout MRI and lung function testing in COPD patients

J Magn Reson Imaging. 2018 Jun;47(6):1534-1541. doi: 10.1002/jmri.25902. Epub 2017 Nov 21.

Authors

Till F Kaireit^{1

2}, Marcel Gutberlet^{1

2}, Andreas Voskrebenzev^{1

2}, Julia Freise³, Tobias Welte^{2

3}, Jens M Hohlfeld^{2

3

4}, Frank Wacker^{1

2}, Jens Vogel-Claussen^{1

2}

Affiliations

¹ Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
² Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hannover, Germany.
³ Clinic of Pneumology, Hannover Medical School, Hannover, Germany.
⁴ Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.

PMID: 29160020
DOI: 10.1002/jmri.25902

Abstract

Background: Ventilation-weighted Fourier decomposition-MRI (FD-MRI) has matured as a reliable technique for quantitative measures of regional lung ventilation in recent years, but has yet not been validated in COPD patients.

Purpose/hypothesis: To compare regional fractional lung ventilation obtained by ventilation-weighted FD-MRI with dynamic fluorinated gas washout MRI (¹⁹ F-MRI) and lung function test parameters.

Study type: Prospective study.

Population: Twenty-seven patients with chronic obstructive pulmonary disease (COPD, median age 61 [54-67] years) were included.

Field strength/sequence: For FD-MRI and for ¹⁹ F-MRI a spoiled gradient echo sequence was used at 1.5T.

Assessment: FD-MRI coronal slices were acquired in free breathing. Dynamic ¹⁹ F-MRI was performed after inhalation of 25-30 L of a mixture of 79% fluorinated gas (C₃ F₈ ) and 21% oxygen via a closed face mask tubing using a dedicated coil tuned to 59.9 MHz. ¹⁹ F washout times in numbers of breaths (¹⁹ F-n_breaths ) as well as fractional ventilation maps for both methods (FD-FV, ¹⁹ F-FV) were calculated. Slices were matched using a landmark driven algorithm, and only corresponding slices with an overlap of >90% were coregistered for evaluation.

Statistical tests: The obtained parameters were correlated with each other using Spearman's correlation coefficient (r).

Results: FD-FV strongly correlated with ¹⁹ F-n_breaths on a global (r = -0.72, P < 0.0001) as well as on a lobar level and with lung function test parameters (FD-FV vs. FEV1, r = 0.76, P < 0.0001). There was a small systematic overestimation of FD-FV compared to ¹⁹ F-FV (mean difference -0.03 (95% confidence interval [CI]: -0.097; -0.045).

Data conclusion: Regional ventilation-weighted Fourier decomposition-MRI is a promising noninvasive, radiation-free tool for quantification of regional ventilation in COPD patients.

Level of evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1534-1541.

Keywords: 19F; COPD; Fourier decomposition; free breathing; lung function tests; washout.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Algorithms
Female
Fluorine-19 Magnetic Resonance Imaging*
Fourier Analysis*
Humans
Image Processing, Computer-Assisted / methods*
Lung / diagnostic imaging*
Magnetic Resonance Imaging*
Male
Middle Aged
Prospective Studies
Pulmonary Disease, Chronic Obstructive / diagnostic imaging*
Respiration
Respiratory Function Tests*