Endoplasmic reticulum in health and disease: the 12th International Calreticulin Workshop, Delphi, Greece

J Cell Mol Med. 2017 Dec;21(12):3141-3149. doi: 10.1111/jcmm.13413. Epub 2017 Nov 21.

Abstract

Starting from 1994, every 2 years, an international workshop is organized focused on calreticulin and other endoplasmic reticulum chaperones. In 2017, the workshop took place at Delphi Greece. Participants from North and South America, Europe, Asia and Australia presented their recent data and discussed them extensively with their colleagues. Presentations dealt with structural aspects of calreticulin and calnexin, the role of Ca2+ in cellular signalling and in autophagy, the endoplasmic reticulum stress and the unfolded protein response, the role of calreticulin in immune responses. Several presentations focused on the role of calreticulin and other ER chaperones in a variety of disease states, including haemophilia, obesity, diabetes, Sjogren's syndrome, Chagas diseases, multiple sclerosis, amyotrophic lateral sclerosis, neurological malignancies (especially glioblastoma), haematological malignancies (especially essential thrombocythemia and myelofibrosis), lung adenocarcinoma, renal pathology with emphasis in fibrosis and drug toxicity. In addition, the role of calreticulin and calnexin in growth and wound healing was discussed, as well as the possible use of extracellular calreticulin as a marker for certain diseases. It was agreed that the 13th International Calreticulin Workshop will be organized in 2019 in Montreal, Quebec, Canada.

Keywords: calcium; calnexin; calreticulin; diseases; endoplasmic reticulum; unfolded protein response (UPR).

Publication types

  • Congress

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics*
  • Amyotrophic Lateral Sclerosis / immunology
  • Amyotrophic Lateral Sclerosis / pathology
  • Animals
  • Autophagy
  • Calcium / metabolism
  • Calnexin / genetics
  • Calnexin / isolation & purification
  • Calreticulin / genetics*
  • Calreticulin / immunology
  • Endoplasmic Reticulum / genetics*
  • Endoplasmic Reticulum / immunology
  • Endoplasmic Reticulum / pathology
  • Endoplasmic Reticulum Stress
  • Gene Expression Regulation
  • Hemophilia A / genetics*
  • Hemophilia A / immunology
  • Hemophilia A / pathology
  • Humans
  • Immunity, Innate
  • Molecular Chaperones / genetics
  • Molecular Chaperones / immunology
  • Neoplasms / genetics*
  • Neoplasms / immunology
  • Neoplasms / pathology
  • Obesity / genetics*
  • Obesity / immunology
  • Obesity / pathology
  • Signal Transduction
  • Unfolded Protein Response
  • Wound Healing / genetics
  • Wound Healing / immunology

Substances

  • Calreticulin
  • Molecular Chaperones
  • calreticulin, human
  • Calnexin
  • Calcium