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The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update

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Review

The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update

Carlo Catassi et al. Nutrients.

Abstract

Gluten-related disorders have recently been reclassified with an emerging scientific literature supporting the concept of non-celiac gluten sensitivity (NCGS). New research has specifically addressed prevalence, immune mechanisms, the recognition of non-immunoglobulin E (non-IgE) wheat allergy and overlap of NCGS with irritable bowel syndrome (IBS)-type symptoms. This review article will provide clinicians with an update that directly impacts on the management of a subgroup of their IBS patients whose symptoms are triggered by wheat ingestion.

Keywords: amylase-trypsin inhibitors (ATIs); celiac disease; gluten sensitivity; gluten-free diet; gluten-related disorders; wheat allergy.

Conflict of interest statement

This paper was made possible by support from Schär for traveling and lodging sponsorship for all co-authors to meet to discuss the object of this paper.

Figures

Figure 1
Figure 1
Potential triggers in wheat that may account for both intestinal and extra-intestinal symptoms.
Figure 2
Figure 2
Wheat components.
Figure 3
Figure 3
IBS treatment pathway.

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References

    1. Ellis A., Linaker B.D. Non-coeliac gluten sensitivity? Lancet. 1978;1:1358–1359. doi: 10.1016/S0140-6736(78)92427-3. - DOI - PubMed
    1. Catassi C., Elli L., Bonaz B., Bouma G., Carroccio A., Castillejo G., Cellier C., Cristofori F., de Magistris L., Dolinsek J., et al. Diagnosis of non-celiac gluten sensitivity (NCGS): The salerno experts’ criteria. Nutrients. 2015;7:4966–4977. doi: 10.3390/nu7064966. - DOI - PMC - PubMed
    1. Sapone A., Bai J.C., Ciacci C., Dolinsek J., Green P.H., Hadjivassiliou M., Kaukinen K., Rostami K., Sanders D.S., Schumann M., et al. Spectrum of gluten-related disorders: Consensus on new nomenclature and classification. BMC Med. 2012;10:13 doi: 10.1186/1741-7015-10-13. - DOI - PMC - PubMed
    1. Catassi C., Bai J.C., Bonaz B., Bouma G., Calabro A., Carroccio A., Castillejo G., Ciacci C., Cristofori F., Dolinsek J., et al. Non-celiac gluten sensitivity: The new frontier of gluten related disorders. Nutrients. 2013;5:3839–3853. doi: 10.3390/nu5103839. - DOI - PMC - PubMed
    1. Tanpowpong P., Ingham T.R., Lampshire P.K., Kirchberg F.F., Epton M.J., Crane J., Camargo C.A., Jr., New Zealand Asthma and Allergy Cohort Study Group Coeliac disease and gluten avoidance in New Zealand children. Arch. Dis. Child. 2012;97:12–16. doi: 10.1136/archdischild-2011-300248. - DOI - PubMed

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