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The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update


The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update

Carlo Catassi et al. Nutrients.


Gluten-related disorders have recently been reclassified with an emerging scientific literature supporting the concept of non-celiac gluten sensitivity (NCGS). New research has specifically addressed prevalence, immune mechanisms, the recognition of non-immunoglobulin E (non-IgE) wheat allergy and overlap of NCGS with irritable bowel syndrome (IBS)-type symptoms. This review article will provide clinicians with an update that directly impacts on the management of a subgroup of their IBS patients whose symptoms are triggered by wheat ingestion.

Keywords: amylase-trypsin inhibitors (ATIs); celiac disease; gluten sensitivity; gluten-free diet; gluten-related disorders; wheat allergy.

Conflict of interest statement

This paper was made possible by support from Schär for traveling and lodging sponsorship for all co-authors to meet to discuss the object of this paper.


Figure 1
Figure 1
Potential triggers in wheat that may account for both intestinal and extra-intestinal symptoms.
Figure 2
Figure 2
Wheat components.
Figure 3
Figure 3
IBS treatment pathway.

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