Multiple-physiological benefits of bird's nest fern (Asplenium australasicum) frond extract for dermatological applications

Nat Prod Res. 2019 Mar;33(5):736-741. doi: 10.1080/14786419.2017.1405400. Epub 2017 Nov 22.


p-coumaric acid and fucose-rich polysaccharide have been studied for many bio-functions in skin including cutaneous protection from oxidative damage and antiageing, respectively, as well as wound healing. The physiological activities of various bird's nest fern extracts (BNFE), containing considerable fucose-rich mucilage and p-coumaric acid, on fibroblast and human skin were first investigated. BNFE with higher polysaccharide content generally contributed to a better moisture holding capability. Furthermore, BNFE showed pronouncedly enhancing effect on collagen production and growth of fibroblast (NIH-3T3), clinical trial results revealed that the emulsions with 1% BNFE showed good moisturising effect and improved the elasticity of human skins effectively. The potential of BNFE for cosmetics and medical applications such as natural moisturiser, antiageing and wound repairing was possibly related to the fucose-rich mucilage and various phenolic compounds including p-coumaric acid in BNFE.

Keywords: -coumaric acid; Bird’s nest fern; collagen; fibroblast; fucose-rich mucilage; skin ageing.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Animals
  • Coumaric Acids / isolation & purification
  • Coumaric Acids / pharmacology*
  • Elasticity
  • Emulsions
  • Female
  • Fibroblasts / drug effects
  • Humans
  • Mice
  • NIH 3T3 Cells
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry
  • Plant Mucilage / isolation & purification
  • Plant Mucilage / pharmacology*
  • Skin / drug effects*
  • Skin Pigmentation
  • Taiwan
  • Tracheophyta / chemistry*
  • Young Adult


  • Coumaric Acids
  • Emulsions
  • Phytochemicals
  • Plant Extracts
  • Plant Mucilage