Whole Y-chromosome Sequences Reveal an Extremely Recent Origin of the Most Common North African Paternal Lineage E-M183 (M81)

Sci Rep. 2017 Nov 21;7(1):15941. doi: 10.1038/s41598-017-16271-y.

Abstract

E-M183 (E-M81) is the most frequent paternal lineage in North Africa and thus it must be considered to explore past historical and demographical processes. Here, by using whole Y chromosome sequences from 32 North African individuals, we have identified five new branches within E-M183. The validation of these variants in more than 200 North African samples, from which we also have information of 13 Y-STRs, has revealed a strong resemblance among E-M183 Y-STR haplotypes that pointed to a rapid expansion of this haplogroup. Moreover, for the first time, by using both SNP and STR data, we have provided updated estimates of the times-to-the-most-recent-common-ancestor (TMRCA) for E-M183, which evidenced an extremely recent origin of this haplogroup (2,000-3,000 ya). Our results also showed a lack of population structure within the E-M183 branch, which could be explained by the recent and rapid expansion of this haplogroup. In spite of a reduction in STR heterozygosity towards the West, which would point to an origin in the Near East, ancient DNA evidence together with our TMRCA estimates point to a local origin of E-M183 in NW Africa.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa, Northern
  • African Continental Ancestry Group / genetics*
  • Base Sequence
  • Bayes Theorem
  • Chromosomes, Human, Y / genetics*
  • Haplotypes / genetics
  • Humans
  • Male
  • Microsatellite Repeats / genetics
  • Phylogeny*
  • Polymorphism, Single Nucleotide / genetics
  • Principal Component Analysis
  • Time Factors