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. 2017 Oct;37(5):393-400.
doi: 10.14639/0392-100X-1709.

Clinical analysis of Hashimoto thyroiditis coexistent with papillary thyroid cancer in 1392 patients

J Liang  1 , W Zeng  1 , F Fang  1 , T Yu  2 , Y Zhao  1 , X Fan  1 , N Guo  1 , X Gao  1
Affiliations

Clinical analysis of Hashimoto thyroiditis coexistent with papillary thyroid cancer in 1392 patients

J Liang et al. Acta Otorhinolaryngol Ital. 2017 Oct.

Abstract
in English, Italian

Papillary thyroid carcinoma (PTC) is the most common malignant tumour of the thyroid. The effect of the concurrent presence of Hashimoto's thyroiditis (HT) and PTC is still under debate. The aim of this study is to investigate the influence of coexistent HT on prognostic outcomes and the association of coexistent HT with clinicopathological features. The demographic and clinicopathological data of 1,392 patients who underwent surgery in our hospital from 2007 to 2016 was collected and analysed. Among 1,392 PTC patients, the rate of HT was 25.6%. There were significant differences in the mean levels of thyroid stimulating hormone (3.27 vs. 2.41 μIU/L, p < 0.01), thyroperoxidase antibodies (110.31 vs. 131.2 U/ml, p < 0.01) and thyroglobulin antibodies (131.90 vs. 113.53 ng/ml, p < 0.01) between the two groups. PTC patients with HT had the following characteristics compared to patients without HT: smaller tumour size (p < 0.01), female predominance (p < 0.01) and higher rate of multifocality (p = 0.024). In addition, patients with HT had a significantly lower rate of lymph node metastasis (LNM) and advanced TNM stage than patients without HT (all p < 0.01). Multivariate analysis found that both age and multifocality were significantly associated with central LNM in HT patients (p < 0.01, p = 0.019, respectively). Extrathyroidal invasion and TSH level were also significant independent factors for lateral LNM in HT patients (p < 0.008, p = 0.04, respectively). HT is associated with a significantly higher risk of PTC. The coexistence of HT in PTC patients is associated with favourable clinical outcomes compared to PTC without HT. Total thyroidectomy and prophylactic central compartment lymphadenectomy should be a choice for PTC patients with HT.

Il carcinoma papillare (PTC) è il più comune tumore maligno della ghiandola tiroide. L’effetto della concomitante presenza della tiroidite di Hashimoto (HT) e del PTC è ancora oggetto di studio. Scopo di questo studio è analizzare la coesistenza di una concomitante HT circa l’outcome prognostico e eventuali associazioni clinico-patologiche. Abbiamo raccolto ed analizzato i dati demografici e clinicopatologici di 1392 pazienti che sono stati sottoposti a chirurgia nel nostro ospedale dal 2007 al 2016. Fra i 1392 pazienti con PTC, la percentuale di coesistente HT era del 25,6%. Vi erano differenze significative tra i due gruppi nei livelli medi di ormone tireostimolante (3.27 vs. 2.41μIU/L, p < 0.01), anticorpi anti tireoperossidasi (110.31 vs. 131.2U/ml, p < 0.01) e anticorpi anti tireoglobulina (131.90 vs. 113.53 ng/ ml, p < 0.01) I pazienti con PTC e HT avevano le seguenti caratteristiche se comparate con quelle dei pazienti senza HT: tumori di dimensioni più piccole (p < 0.01), predominanza del sesso femminile (p < 0.01) ed un piu’ alto tasso di multifocalita’(p = 0.024). Inoltre, i pazienti con HT avevano un tasso significativamente basso di metastasi linfonodali (LNM) ed uno stadio di TNM più elevato rispetto ai pazienti senza HT (tutti p < 0.01). L’analisi multivariata ha evidenziato come età e multifocalità erano significativamente associate con metastasi nel compartimento centrale nei pazienti con HT (p < 0.01, p = 0.019, rispettivamente). L’invasione extratiroidea ed i livelli di TSH erano fattori significativamente indipendenti per le metastasi linfonodali laterocervicali nei pazienti con HT (p < 0.008, p = 0.04, rispettivamente). HT era associata ad un maggior rischio di sviluppare PTC. La coesistenza di HT in pazienti con PTC favoriva un miglior outcome clinico rispetto a quei pazienti con PTC ma senza HT. La tiroidectomia totale associata allo svuotamento del compartimento centrale deve essere la prima scelta chirurgica nei pazienti con PTC e HT.

Keywords: Clinicopathologic characteristics; Hashimoto’s thyroiditis; Papillary thyroid cancer.

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Figures

Fig. 1.
Fig. 1.
Comparison of disease-free survival between groups.
Fig. 2.
Fig. 2.
Comparison of overall survival between groups.
See this image and copyright information in PMC

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References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5–29. - PubMed
    1. Jiwang L, Zhendong L, Shuchun L, et al. Clinicopathologic characteristics of familial versus sporadic papillary thyroid carcinoma. Acta Otorhinolaryngol Ital. 2015;35:234–242. - PMC - PubMed
    1. Cho BY, Choi HS, Park YJ, et al. Changes in the clinicopathological characteristics and outcomes of thyroid cancer in Korea over the past four decades. Thyroid. 2013;23:797–804. - PMC - PubMed
    1. Vanderpump MP, Tunbridge WM, French JM, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf) 1995;43:55–68. - PubMed
    1. Jankovic B, Le KT, Hershman JM. Clinical review: Hashimoto’s thyroiditis and papillary thyroid carcinoma: is there a correlation? J Clin Endocrinol Metab. 2013;98:474–482. - PubMed